Splice is a horror thriller executive produced by Guillermo del Toro and directed by Vincenzo Natali.

The film stars Adrien Brody and Sarah Polley as Clive and Elsa – superstars of the genetic engineering world. They specialize in splicing together DNA from different animals to create fantastical new hybrids. The charismatic couple wants to use human DNA in a new hybrid – something that could yield astronomical medical benefits. The pharmaceutical company that funds their research, however, is more interested in exploiting their earlier triumphs for easier, short-term profit. Clive and Elsa secretly conduct their own experiment. The result is Dren: an amazing creature who exhibits an array of unexpected developments, both physical and intellectual. Dren exceeds their wildest dreams… and, ultimately, their most terrifying nightmare.

[Source] IGN