Milla Jovovich is talking about Resident Evil 4: Afterlife, which starts shooting later this year. She has confirmed that her husband, Paul WS Anderson, will direct as well as produce, and that he’s reasearching 3D techniques in order to shoot this chapter in the format. She’s also given a bit of info about what we’ll be likely to see, storywise, and it sounds like Jovovich will be busy. 

Let’s just say this. The clones are definitely in it. You’ve got multiple Alice’s kicking serious butt. And definitely the real Alice has some pretty major things happen to her that change the stakes a little bit. That’s probably all I can give you in a vague sort of way. It’s definitely going to be a different Alice than who we’re used to…There’s the clones and it’s going to be a lot of work. I’m gonna be working every day for the next four months on this and it’s gonna be bigger than ever. It’s super-exciting.”

[Source] B-D