This film picks up a few days later after the first film ended. The fatally wounded Paul has been laying in the stream nearly lifeless for a few days. While he has been laying there the virus has grown and evolved in his body. Paul now suffers from hideous lumps on his face and body with oozing lumps, sores, and blisters. Paul strives to survive as he finally gains the strength to get up out of the stream, but fails as he dies a shockingly painful death by a school bus. The down home water trucking company has collected water for distribution. Two of the truck drivers die horribly after consuming the contaminated water, after it has been dropped off at a school the day of the prom. At the prom, the punch, which gets infected by bodily fluids, is now contaminated with the virus causing the outbreak to begin. After a while the kids at prom begin to feel nauseous and start developing hideous blood blisters, flesh eating sores, blood vomiting, and start to convulse in a seizure like manner. The school is then on lock down, and the few that were not infected try to survive what they have just witnessed.

Ti West filmed Cabin Fever 2: Spring Fever a couple years back. Since he finished the film West has tried his best to dance around the subject but doesn’t believe the movie is his anymore. While at the UK FrightFest he said that Lionsgate has finally recut the film and that he officially wants to “disown it”.